After trying a number of different medications, John Moden said nothing seemed to be effectively treating his depression.

Moden, of Swartz, said he would feel anxious and stressed all the time, making it hard for him to sleep at night and to fully appreciate life.

That was until he tried Transcranial Magnetic Stimulation therapy, which uses highly focused magnetic pulses to stimulate key neurons in the brain.

“Now I’m more relaxed, and once you can relax, you see the need to smell the flowers,” he said. “You can enjoy various things you wouldn’t have before.”

Neuroimaging may help in determining the best first-line treatment for patients with major depressive disorder (MDD), a new study suggests.

Results showed that pretreatment brain activity in the right anterior insula on positron emission tomography (PET) predicted whether depressed patients would best achieve remission with an antidepressant or cognitive-behavioral therapy (CBT).

There hasn’t been much in the way of hard science to help doctors or patients decide on the best treatments for depression - until now. For the first time, brain imaging may be able to help determine who will get better in therapy and who improves more on medication.

Depression affects an estimated 1 in 5 people over a lifetime, and talk therapies and antidepressant medications can help a significant proportion of those patients. But figuring out who will benefit most from which treatments remains a major challenge; while nearly 22 million Americans take antidepressants, 40% of people are not helped by the first treatment — drug or talk therapy — they try. And since it often takes weeks to relieve symptoms, choosing the wrong first treatment can lead to extra months of suffering.

The outlawing of drugs such as cannabis, magic mushrooms and other psychoactive substances amounts to scientific censorship and is hampering research into potentially important medicinal uses, leading scientists argue.

Laws and international conventions dating back to the 1960s have set back research in key areas such as consciousness by decades, they argued in the journal Nature Reviews Neuroscience.

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